Tumor-Specific Immune Mechanisms

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Abstract
Summary of Immunologic Surveillance and Escape MechanismsIn commenting upon possible evolutionary or selective pressures that resulted in transplantation immunity in mammals, Thomas98 proposed, in 1958, that this mechanism best met the need for surveillance and destruction of somatically altered cells that had escaped from normal metazoan growth controls. Establishment that neoplastic transformation of cells is inevitably associated with a newly acquired antigenicity of the evolving clone provided a key element previously missing. Support for this hypothesis is that the rejection of autochthonous or syngeneic MCA tumors may occur as a result of direct activity of the lymphoreticular system. Moreover, . . .