LINEAR ENERGY TRANSFER-DEPENDENT RADIOSENSITIVITY OF BURKITT-LYMPHOMA CELLS, WITH SPECIAL REFERENCES TO HUMAN MELANOMA HMV, HELA-S3, AND L5178Y CELLS

  • 1 January 1976
    • journal article
    • research article
    • Vol. 67  (3) , 399-402
Abstract
Dependence of the survival curves of Burkitt lymphoma cells, which were featured by their small n or Dq values, on linear energy transfer (LET) obtained for different quality of radiation was revealed in the change of DO value, together with a small change in n value. Relative biological effectiveness (RBE) compared with Dq, n and D37 values of Burkitt lymphoma cells for high LET radiation was smaller than that of other cell lines. This finding supports the hypothesis that in Burkitt lymphoma cells the recovery capacity from sublethal damage (Dq) is so small even after low LET irradiation that LET does not modify the suppression of recovery. Similar survival curves with n value closely equal to 1 were obtained for 4 mammalian cell lines (Burkitt lymphoma P3HR-1, human melanoma HMV, HeLa-S3 cervical cancer and L5178Y mouse leukemia) after 2 MeV neutron irradiation. This fact may suggest that the radiation which has an LET value at which the n value of the survival curve is 1 will be optimum for therapeutic purpose in radioresistant tumors.

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