ACUTE EFFECTS OF VARYING DOSES OF PROPRANOLOL UPON OXYGEN HAEMOGLOBIN AFFINITY IN MAN
Open Access
- 1 February 1974
- journal article
- Published by Wiley
- Vol. 1 (1) , 67-70
- https://doi.org/10.1111/j.1365-2125.1974.tb00208.x
Abstract
1 The effect of propranolol 2 h following doses of 10, 30, or 100 mg upon the blood oxygen-haemoglobin dissociation curves has been studied in four normal subjects. 2 The pO2 at 50% saturation (p50) was not changed significantly under control conditions or after 10 and 100 mg doses. There was a just significant increase of 2 mmHg in the p50 value after the 30 mg dose. 3 There was no significant change in red cell adenosine triphosphate or 2, 3-diphospho-glycerate nor in plasma phosphate. 4 There was no correlation between plasma propranolol concentration and changes in blood p50.Keywords
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