Qualitative and Quantitative Changes in Uterine mRNA Populations in Response to Oestradiol Treatment of Rats
- 1 October 1979
- journal article
- research article
- Published by Wiley in European Journal of Biochemistry
- Vol. 100 (1) , 95-100
- https://doi.org/10.1111/j.1432-1033.1979.tb02037.x
Abstract
The mRNA population of immature rat uteri, responding to different lengths of estradiol[E2]-induced differentiation, were compared by the technique of DNA hybridization with heterogeneous RNA. Over the first 4 h of hormone induction there are continuing qualitative and quantitative changes in the poly(A)-containing mRNA such that, by 4 h after E2 administration, the population bears little resemblance to that of the unstimulated animal. Between 2 h and 4 h after E2 administration, the most striking changes appear to be in sequences of intermediate abundance. The possible significance of these findings is discussed.This publication has 20 references indexed in Scilit:
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