Change in Ig Expression of a Human Lymphoblastoid Line During Long‐Term Culture

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Abstract
A human lymphoblastoid line, in continuous culture for over 3 years, showed changes in Ig expression with time. The following pattern of events was suggested by studies of Ig synthesis and secretion performed at intervals. In a mass culture containing a heterogeneous cell population, Ig expression may shift because of selection acting on the different phenotypes. In human lymphoblastoid lines there may be a tendency for selection to favor IgMx‐producing cells. In clones, including those that synthesize multiple H chains, substantial determinism for Ig expression is present.