Pharmacology of a Short-Acting Non-Sulphur Barbituric Acid Derivative

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Abstract
A new compound, l_methyl-5-allyl-(1-methyl-2-pentynyl) barbituric acid, sodium salt, (No. 22451) was studied and com. pared with Pentothal (theopental sodium) and Thioseconal in rats, rabbits, dogs and monkeys. It is a more potent anesthetic than either Pentothal or Thioseconal. With an observed AD60 this compound has a shorter duration of anesthetic action than the two thio-compounds. When 1/2 of the AD50 is injected by vein at hourly intervals, No. 22451 has less cumulative action than Pentothal or Thioseconal. After prolonged anesthesia, recovery time is much more rapid with this agent than with Pentothal or Thioseconal and, as other experiments show, this transient action is related to detoxification by the liver.