Hypervirulence of a Rough Variant of the Mycobacterium abscessus Type Strain
- 1 February 2007
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 75 (2) , 1055-1058
- https://doi.org/10.1128/iai.00835-06
Abstract
We isolated a rough variant of Mycobacterium abscessus CIP 104536T during experimental infection of mice. We show that this variant has lost the ability to produce glycopeptidolipids, is hyperlethal for C57BL/6 mice infected intravenously, and induces a strong tumor necrosis factor-alpha response by murine monocyte-derived macrophages.Keywords
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