Invasive Squamous Cell Carcinoma of the Uterine Cervix Vii. Influence of Vehicle Osmolarity on Biopsy Quality
- 1 January 1983
- journal article
- research article
- Published by Taylor & Francis in Acta Radiologica: Oncology
- Vol. 22 (4) , 257-261
- https://doi.org/10.3109/02841868309134039
Abstract
A histopathologic grading system for more reliable determination of the prognosis in individual patients with squamous cell carcinoma of the uterine cervix necessitates better sampling and fixation techniques. Fixation in 10 per cent formalin and 0.17 mol phosphate buffer at pH 7.0, with an effective osmolarity of 350 mmol/l, gave optimal stainability, and minimized tissue shrinkage and sectioning artefacts. Vessels remained open, which facilitated the analysis of vascular invasion. A newly designed biopsy forceps yielded large and representative specimens with a minimum of pressure distortion.Keywords
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