Creatine, 2,3-Diphosphoglycerate and Anemia

Publisher Website
Google Scholar
Abstract
Red-cell creatine and 2,3-diphosphoglycerate were investigated in normal persons, in patients with anemia characterized by increased age of the red-cell population (aplastic anemias), and in patients with anemias characterized by a young red-cell population (hemolytic and other bone-marrow-responsive anemias). The mean age of the red-cell population was estimated by hexokinase and glutamic oxalacetic transaminase activities. In anemias with older red-cell populations creatine levels were found to be very low, whereas the 2,3-diphosphoglycerate values were slightly increased. In anemias with a younger mean age of the red cells there was an increase in both creatine and 2,3-diphosphoglycerate. Thus, it appears that increases in creatine are chiefly related to the mean age of the red-cell population, whereas those in 2,3-diphosphoglycerate are conditioned both by the anemia and by the age of red cells.

This publication has 15 references indexed in Scilit: