Studies on transformation of Syrian hamster cells by simian virus 40 (SV40): acquisition of oncogenicity by virus-exposed cells apparently unassociated with the viral genome.
- 1 October 1965
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 54 (4) , 1092-1099
- https://doi.org/10.1073/pnas.54.4.1092
Abstract
Lines of Syrian hamster lung and liver cells originally exposed as primary cultures to large doses of SV40 exhibited increased growth rate, high plating efficiency, morphological transformation, and, in some instances, oncogenic potential after unusually long intervals. In at least 2 lines acquisition of oncogenic potential occurred independently of morphological transformation. In none of a total of 11 cell lines studied in detail was conclusive evidence for the presence of the SV40 genome obtained.This publication has 15 references indexed in Scilit:
- Induction of cellular DNA synthesis by polyoma virus.Proceedings of the National Academy of Sciences, 1965
- STEPS IN THE NEOPLASTIC TRANSFORMATION OF HAMSTER EMBRYO CELLS BY POLYOMA VIRUSProceedings of the National Academy of Sciences, 1963
- Morphology and Distribution of SV40-Infected Cells in Human, Simian and Hamster Renal Cell Cultures as Detected by Immunofluorescence.Experimental Biology and Medicine, 1963
- TRANSFORMATION INDUCED BY SIMIAN VIRUS 40 IN NEWBORN SYRIAN HAMSTER RENAL CELL CULTURESProceedings of the National Academy of Sciences, 1963
- SV40-induced ependymomas in newborn hamstersVirology, 1962
- TRANSFORMATION INDUCED BY SIMIAN VIRUS 40 IN HUMAN RENAL CELL CULTURES, I. MORPHOLOGY AND GROWTH CHARACTERISTICS *Proceedings of the National Academy of Sciences, 1962
- Identification of the oncogenic substance in rhesus monkey kidney cell cultures as simian virus 40Virology, 1962
- Assessment of potential malignancy of cultured cells: further observations on the differentiation of "normal" and "neoplastic" cells maintained in vitro by hetero-transplantation in Syrian hamsters.1962
- Multiplication and Cytopathogenicity of Simian Vacuolating Virus 40 in Cultures of Human Tissues.Experimental Biology and Medicine, 1962
- Propagation in Tissue Cultures of Cytopathogenic Agents from Patients with Measles.Experimental Biology and Medicine, 1954