Evidence for the Conversion of Carbon Monoxide to Carbon Dioxide by the Intact Animal

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Abstract
Oxidation of CO to CO2 in turtles and mice is demonstrated by measuring the rate of disappearance of CO from a closed system containing the animals, and by demonstration of radioactivity in expired CO2 from animals in an atmosphere containing radioactive CO. In 8-13 days 2080-4880 g. of turtles absorbed 30-52% of CO from 60 1. of 0.023% to 0.075% CO. In 12.5 1. of 0.071 and 0.089% CO for 4 days, 246 g. and 294 g. of mice consumed 0.2 and 0.26 mm3/g./hr., respectively. In 2 expts. in 0.07% C14O with 51 g. and 47 g. of mice, 22.3 and 19.3% of C14, respectively, appeared in CO2 after 2.67 and 2 days, conversion being accomplished at rates of 0.28 and 0.29 mm3/g./hr.

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