Changes in prostaglandin levels in the sensitized and non-sensitized uterus of the mouse after the intrauterine instillation of oil or saline

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Abstract
Intrauterine instillation of oil, but not saline, induced both a decidual cell reaction and a marked elevation in the uterine PG[prostaglandin]F.alpha. content of suitably sensitized ovariectomized mice. Uterine PGF.alpha. concentrations were elevated within 5 min of the oil instillation, reached maximal levels within 30-60 min and then declined to near baseline levels again by 3 h. A similar increase in uterine PGF.alpha. content in response to oil instillation was seen in non-sensitized females, although no decidual cell reaction developed. No significant changes in PGE or 6-oxo-PGF1 content were observed. Although the increase in uterine PGF.alpha. content is not solely due to the distension of the uterus after intrauterine injection, the increase is not necessarily sufficient to induce a decidual cell reaction.