The kinetics of immune tolerance to human serum albumin induced in sublethally x-irradiated rabbits.

  • 1 September 1968
    • journal article
    • Vol. 15  (3) , 343-55
Abstract
Kinetic studies of immune tolerance induction to HSA in sublethally X-rayed rabbits revealed that tolerance can be induced in this system with small amounts of antigen which in non-irradiated animals would constitute small immunizing doses. This, however, depends on a proper schedule of antigen administration which has to be spread over the 8 weeks of post-radiation recovery, although tolerance can be induced by this method even when this antigen treatment is postponed as long as 4 weeks after X-irradiation.