EFFECTS OF ADRENERGIC-BLOCKADE ON PLASMA CATECHOLAMINE LEVELS DURING ADRENALINE INFUSION

  • 1 January 1979
    • journal article
    • research article
    • Vol. 11  (1) , 52-57
Abstract
Alpha and beta adrenergic blocking drugs were administered, either singly or in combination, prior to a 3 h adrenaline [epinephrine] infusion (2 .mu.g kg body wt-1 min-1). Animals [sheep] were premedicated with either phenoxybenzamine (1 mg kg body wt-1 min-1) and/or propranol 7 .mu.g kg body wt-1 min-1). Phenoxybenzamine did not affect circulating adrenaline levels, but propranolol, either alone or in combination with phenoxybenzamine, resulted in a significant reduction in plasma adrenaline levels when compared with the control unblocked situation of adrenaline infusion without premedication. A possible explanation for the protective effect of adrenergic blockade in shock situations is provided.

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