Clotting and Hemorrhage in the Placenta — A Delicate Balance

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Abstract
Increased susceptibility to deep-vein thrombosis is a well-known facet of pregnancy and the puerperium, with the greatest risk occurring during the puerperium. It remains unclear, however, whether a genetically determined tendency toward clot formation in the mother can affect the fetus or cause obstetrical complications. It is important to clarify this issue because mutations and polymorphisms that contribute to a susceptibility to thrombosis — the inherited thrombophilias — occur in up to 20 percent of persons of European descent.In 1999, the Journal published a report on a case–control study by Kupferminc et al., which showed that a hypercoagulable state . . .