Increase of Hexobarbital Sleeping Time by Certain Anticholinesterases.
- 1 July 1958
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 98 (3) , 650-652
- https://doi.org/10.3181/00379727-98-24139
Abstract
The anticholinesterases OMPA, EPN, malathion, chlorothion and phostex increased hexobarbital sleeping time in mice 2 to 4 times, while BFP and TEPP were ineffective. TEPP hastened the onset of action of barbital while chlorothion did not. Anticholinesterases which are rapidly metabolized by the liver may complete for enzymes which are responsible for the destruction of hexobarbital.Keywords
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