Coxsackie B3 Myocarditis in Athymic Mice

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Abstract
Coxsackievirus B3 produces myofiber necrosis and mononuclear infiltration in the hearts of both BALB/c and athymic mice within 8 days after infection. Viral clearance time from the myocardium of both athymic and BALB/c mice did not differ. Within 2 wk of infection both strains of mice develop chronic inflammatory infiltrates comprised of cells that were diffusely and intensely acid-.alpha.-naphthyl esterase positive and characteristic of monocytes or showed only focal esterase staining characteristic of T lymphocyte lineage.

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