STUDIES WITH THE ELECTRON MICROSCOPE OF VIRUS-HOST RELATIONSHIPS IN EHRLICH ASCITES TUMOR CELLS

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Abstract
The identification of certain particles found in the cytoplasm of sectioned tumor cells as the inoculated virus is proposed on the basis of their consistent size and internal structure, their opacity, the appearance of major foci after a certain time interval, and of similar particles in infected chorioallantoic membrane. Particles are frequently embedded in a matrix, and their alignment, grouping and the location of foci discussed. Some infective changes in the cell e.g., the formation of necrotic regions are described. The spheroid particles consist of a transparent 25 to 30 m[mu] core, surrounded by an opaque complex shell 12 to 17 m[mu] thick, containing apparently hollow sub units. The validity of an additional outer envelope is discussed.