19F NMR spectroscopy study of the metabolites of flucloxacillin in rat urine
- 1 December 1985
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 37 (12) , 869-873
- https://doi.org/10.1111/j.2042-7158.1985.tb04991.x
Abstract
19F NMR spectroscopy was used to monitor the metabolites of flucloxacillin in the urine of a rat dosed with its sodium salt. 19F NMR signals were detected and quantified from flucloxacillin and three metabolites. The 19F NMR method involves minimal sample preparation and is free from interference by endogenous urine components. High-field spin-echo 1H NMR spectroscopy and HPLC were used to confirm the results.This publication has 10 references indexed in Scilit:
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