ER stress and neurodegenerative diseases
Top Cited Papers
- 6 January 2006
- journal article
- review article
- Published by Springer Nature in Cell Death & Differentiation
- Vol. 13 (3) , 385-392
- https://doi.org/10.1038/sj.cdd.4401778
Abstract
Endoplasmic reticulum (ER) stress is caused by disturbances in the structure and function of the ER with the accumulation of misfolded proteins and alterations in the calcium homeostasis. The ER response is characterized by changes in specific proteins, causing translational attenuation, induction of ER chaperones and degradation of misfolded proteins. In case of prolonged or aggravated ER stress, cellular signals leading to cell death are activated. ER stress has been suggested to be involved in some human neuronal diseases, such as Parkinson's disease, Alzheimer's and prion disease, as well as other disorders. The exact contributions to and casual effects of ER stress in the various disease processes, however, are not known. Here we will discuss the possible role of ER stress in neurodegenerative diseases, and highlight current knowledge in this field that may reveal novel insight into disease mechanisms and help to design better therapies for these disorders.Keywords
This publication has 70 references indexed in Scilit:
- The ubiquitin proteasome system in synaptic and axonal degenerationThe Journal of cell biology, 2004
- Coupling endoplasmic reticulum stress to the cell death programCell Death & Differentiation, 2004
- A decade of caspasesOncogene, 2003
- Regulation of apoptosis by endoplasmic reticulum pathwaysOncogene, 2003
- The Ubiquitin Proteasome System in Neurodegenerative Diseases: Sometimes the Chicken, Sometimes the EggPublished by Elsevier ,2003
- Unfolding the role of protein misfolding in neurodegenerative diseasesNature Reviews Neuroscience, 2003
- ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeatsGenes & Development, 2002
- Endoplasmic reticulum dysfunction – a common denominator for cell injury in acute and degenerative diseases of the brain?Journal of Neurochemistry, 2001
- An Unfolded Putative Transmembrane Polypeptide, which Can Lead to Endoplasmic Reticulum Stress, Is a Substrate of ParkinPublished by Elsevier ,2001
- Impairment of the Ubiquitin-Proteasome System by Protein AggregationScience, 2001