Adrenal Medullary Hormones in Water Diuresis.

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Abstract
Doses of adrenal medullary hormones suspended in oil and varying from 3-30 [mu]g./100 g. of body wt. were admn. to rats by subcut. injn. The diuretic effect elicited by Adrenalin, dl-nor-epinephrine, 1-nor-epinephrine and 1,-epineph-rine was compared with that obtained in non-treated controls. The Adrenalin (Parke-Davis) was predominantly 1-epinephrine but contained small amts. of nor-epinephrine. It was found at either dosage level that injn. of nor-epinephrine compounds were more effective in causing an augmentation of water diuresis than was the injn. of Adrenalin. Pure 1-epinephrine had no stimulating action on diuresis. Further expts. were made to study the effects that dibenamine and medullectomy would have on the action of the above mentioned hormones in water diuresis. It was found that dibenamine caused a water retention in intact rats but failed to do so in medullectomized rats. Dibenamine blocked and reversed the diuretic activity of Adrenalin in intact rats but it less effectively blocked such activity of nor-epinephrine. Dibenamine in the dosage used (0.5 mg,/100 g. body wt.) was incapable of blocking the action of nor-epinephrine in medullectomized animals. These results indicate that the diuretic action of adrenal medullary hormone probably was due to nor-epinephrine.

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