Block of T -Type Ca2+ Channels Is an Important Action of Succinimide Antiabsence Drugs
- 1 March 2002
- journal article
- Published by SAGE Publications in Epilepsy Currents
- Vol. 2 (2) , 49-52
- https://doi.org/10.1046/j.1535-7597.2002.00019.x
Abstract
The role of calcium channel blockade in the antiepileptic action of ethosuximide is controversial, especially regarding the potency and efficacy of block. However, recent evidence obtained from transgenic animals and heterologous expression systems supports a major role of T-type calcium channels in both the generation of absence seizures and the action of ethosuximide in human absence epilepsy.Keywords
This publication has 24 references indexed in Scilit:
- Block of Cloned Human T-Type Calcium Channels by Succinimide Antiepileptic DrugsMolecular Pharmacology, 2001
- Lack of the Burst Firing of Thalamocortical Relay Neurons and Resistance to Absence Seizures in Mice Lacking α1G T-Type Ca2+ ChannelsNeuron, 2001
- Regulation of the calcium channel α1G subunit by divalent cations and organic blockersNeuropharmacology, 2000
- Neonatal Seizures: Historic Note and Present ControversiesEpilepsia, 1996
- Thalamocortical Oscillations in the Sleeping and Aroused BrainScience, 1993
- Cellular Mechanisms of a Synchronized Oscillation in the ThalamusScience, 1993
- Differential effects of petit mal anticonvulsants and convulsants on thalamic neurones: calcium current reductionBritish Journal of Pharmacology, 1990
- Calcium currents in rat thalamocortical relay neurones: kinetic properties of the transient, low‐threshold current.The Journal of Physiology, 1989
- Characterization of ethosuximide reduction of low‐threshold calcium current in thalamic neuronsAnnals of Neurology, 1989
- Specific petit mal anticonvulsants reduce calcium currents in thalamic neuronsNeuroscience Letters, 1989