SERUM TESTOSTERONE AND DIHYDROTESTOSTERONE IN PATIENTS WITH TROPHOBLASTIC DISEASE

  • 1 January 1976
    • journal article
    • research article
    • Vol. 47  (6) , 684-688
Abstract
Serum Testosterone (T) and dihydrotestosterone (DHT) were measured by radioimmunoassay in 14 patients with unaborted hydatidiform mole and 16 patients with normal pregnancy of similar gestational age. Serum human chorionic gonadotropin (hCG) was measured by the radioreceptor assay in patients with hydatidiform mole. Serum T ranged from 0.27-5.39 ng/ml with a mean .+-. SE of 2.21 .+-. 0.45 ng/ml in patients with hydatidiform mole mole and from 0.20-2.40 ng/ml with a mean .+-. SE of 0.80 .+-. 0.14 ng/ml in patients with normal pregnancy, the difference statistically significant (P < 0.005). Patients with molar pregnancies had a significantly higher (P < 0.005) serum DHT (range: 0.09-0.62 ng/ml; mean .+-. SE: 0.29 .+-. 0.05 ng/ml) than patients with normal pregancies (range: 0.04-0.28 ng/ml; mean .+-. SE: 0.12 ng/ml). There was no significant correlation between uterine size or serum hCG and serum T or DHT. The possible sources of the elevated serum T and DHT and the lack of hirsutism or virilization in patients with trophoblastic disease are discussed.

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