Asymmetric synthesis of alcohols with two chiral centres from a racemic aldehyde by the selective addition of dialkylzinc reagents using (1S,2R)-(–)-N,N-dibutylnorephedrine and (S)-(+)-diphenyl-(1-methylpyrrolidin-2-yl)methanol as chiral catalysts
- 1 January 1990
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 9,p. 709-711
- https://doi.org/10.1039/c39900000709
Abstract
Optically active alcohols with two chiral centres were obtained in up to 93% enantiomeric excess by the selective addition of dialkylzinc reagents to the racemic aldehyde, 2-phenylpropanal, using the title compounds as chiral catalysts.Keywords
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