Secretion of Calcitonin Gene-Related Peptide from Baby Rat Thyroid Glands in Vitro
- 1 December 1985
- journal article
- letter
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 180 (3) , 562-566
- https://doi.org/10.3181/00379727-180-rc2
Abstract
Thyroid glands from 8-day-old rat pups were incubated in serum-free medium for 6 hr. Both calcitonin (CT) and calcitonin gene-related peptide (CGRP) released into medium were measured by radioimmunoassay. In 6 separate experiments CGRP was easily detected in medium in ng/ml concentrations. In 4 of the 6 experiments, where CT release was stimulated by high medium [Ca], the concentration of CGRP in medium showed a positive, significant correlation with the medium CT concentration (r = 0.41=0.69, p < .05 - < .01). The results are in concert with reports describing the presence of CGRP in the C-cell, and they further show that CGRP, as well as CT, can be secreted by C-cell.This publication has 8 references indexed in Scilit:
- Interaction of Calcitonin and Calcitonin Gene-Related Peptide at Receptor Sites in Target TissuesScience, 1985
- Calcitonin gene-related peptide and its binding sites in the human central nervous system and pituitary.Proceedings of the National Academy of Sciences, 1985
- Immunoreactive calcitonin gene-related peptide and substance P coexist in sensory neurons to the spinal cord and interact in spinal behavioral responses of the ratNeuroscience Letters, 1984
- Effects of calcitonin gene-related peptide on food intakePeptides, 1984
- Intraventricular calcitonin gene-related peptide inhibits gastric acid secretionPeptides, 1984
- Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processingNature, 1983
- Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide productsNature, 1982
- In VitroSecretion of Immunoreactive Rat Thyrocalcitonin12Endocrinology, 1977