111In-oxine-labelled white blood cells in the diagnosis and follow-up of crohn's disease

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Abstract
Prospectively, 43 patients with Crohn's disease (41 clinically active, 2 clinically inactive) and 7 patients with irritable bowel syndrome were examined by111In-oxine-labelled leukocytes (‘mixed’ leukocyte preparations,n=8; ‘pure’ granulocyte preparations,n=42). The number of scintigraphically diagnosed inflamed bowel segments correlated significantly (r=0,95,pr=+0.69,pr=−0.54,pr=+0.65,pr=+0.67,p<0.001). In the follow-up of 9 patients, the percentage of fecal excretion decreased or increased more rapidly, but in correlation with the CDAI, A.I., or ESR. The authors conclude that this method is an alternative to common methods and that it is superior in primary diagnosis in patients with severe disease, bowel stenosis, abscesses, and after surgery. After clinical and biopsy-proven diagnosis of Crohn's disease, the special value of the leukocyte scan lies in the noninvasive follow-up of patients and its potential of localizing inflamed bowel segments and assessing disease activity.