Induction by aerosol allergen of sustained and nonspecific IgE-mediated airway hyperreactivity in the guinea pig
- 1 November 1992
- journal article
- research article
- Published by Springer Nature in Inflammation Research
- Vol. 37 (3-4) , 201-203
- https://doi.org/10.1007/bf02028109
Abstract
Described is a guinea pig model of allergic asthma, in which animals are sensitized by intraperitoneal injections of ovalbumin complexed with aluminum hydroxide to elicit an IgE response. Aerosol exposure to ovalbumin induces acute bronchoconstriction and nonspecific airways hyperreactivity, evaluated by intravenous challenges of histamine or acetylcholine. This model mimics the hallmark features of human asthma, is induced by respired allergen and is pharmacologically modulated by prophylactic drugs (methyl prednisolone, ketotifen, theophylline) and the competitive PAF receptor antagonist SDZ 264-412.Keywords
This publication has 8 references indexed in Scilit:
- The booster injection of antigen during active sensitization of guinea‐pig modifies the anti‐anaphylactic activity of the PAF antagonist WEB 2086British Journal of Pharmacology, 1990
- Inhibition of antigen-induced airway hyperresponsiveness, but not acute hypoxia nor airway eosinophilia, by an antagonist of platelet-activating factor.The Journal of Immunology, 1990
- Prevention of non-specific airway hyperreactivity after allergen challenge in guinea-pigs by the PAF receptor antagonist SDZ 64-412British Journal of Pharmacology, 1990
- Repeated antigen challenge induces airway hyperresponsiveness with tissue eosinophilia in guinea pigsJournal of Applied Physiology, 1989
- Inflammatory Mediators Involved in Antigen-induced Airway Microvascular Leakage in Guinea PigsAmerican Review of Respiratory Disease, 1988
- Ozone-induced Bronchial Hyperresponsiveness in the Rat Is Not Accompanied by Neutrophil Influx or Increased Vascular Permeability in the TracheaAmerican Review of Respiratory Disease, 1988
- The effect of the selective PAF antagonist BN 52021 on PAF- and antigen-induced bronchial hyper-reactivity and eosinophil accumulationEuropean Journal of Pharmacology, 1988
- Interactions between Granulocytes and Platelets with the Guinea-Pig Lung in Passive Anaphylactic Shock. Correlations with PAF-Acether-Induced LesionsInternational Archives of Allergy and Immunology, 1987