SELECTIVE DESTRUCTION OF ADRENAL CORTEX BY PULSE DOSES OF DERIVATIVES OF 12-METHYLBENZ(a)ANTHRACENE
- 1 March 1969
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 62 (3) , 704-707
- https://doi.org/10.1073/pnas.62.3.704
Abstract
Pulse doses of emulsions of ten polynuclear aromatic hydrocarbons were found to destroy the adrenal cortex selectively. The corticolytic hydrocarbons are derivatives of 12-methylbenz(a)anthracene which possess at position 7 an alkyl, methoxymethyl, formyl, or hydroxyalkyl group. It would appear that the active corticolytic agent is 7-hydroxyalkyl-12-methylbenz(a)anthracene, of chemical source or generated in metabolism.Keywords
This publication has 9 references indexed in Scilit:
- Composition and preparation of experimental intravenous fat emulsions.1969
- Adrenal destruction and cancer induced by hydroxyalkyl derivatives of 7, 12-dimethylbenz(a)anthraceneBiochemical Pharmacology, 1967
- METABOLISM OF POLYCYCLIC COMPOUNDS. THE METABOLISM OF 7,12-DIMETHYLBENZ[α]ANTHRACENE BY RAT-LIVER HOMOGENATESBiochemical Journal, 1965
- Production and Prevention of Two Distinctive Kinds of Destruction of Adrenal CortexNature, 1965
- AROMATIC AZO DERIVATIVES PREVENTING MAMMARY CANCER AND ADRENAL INJURY FROM 7,12-DIMETHYLBENZ(a)ANTHRACENEProceedings of the National Academy of Sciences, 1965
- INHIBITORY EFFECT OF POLYNUCLEAR HYDROCARBONS AND AMPHENONE ANALOGS ON INDUCTION OF ACUTE ADRENAL NECROSIS BY 7,12-DIMETHYLBENZ[A]ANTHRACENE1963
- Organ Lesions Produced by Hexadimethrine and their Modification by Various AgentsPharmacology, 1963
- MASSIVE ADRENAL NECROSIS IN RATS CAUSED BY 9,10-DIMETHYL-1,2-BENZANTHRACENE AND ITS INHIBITION BY METYRAPONEThe Lancet, 1962
- SELECTIVE ADRENAL NECROSIS AND APOPLEXY INDUCED BY 7,12-DIMETHYLBENZ(a)ANTHRACENEThe Journal of Experimental Medicine, 1961