MODIFICATION OF THE ANTINOCICEPTIVE EFFECT OF MORPHINE BY CENTRALLY ADMINISTERED DIAZEPAM AND MIDAZOLAM
Open Access
- 1 April 1982
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 75 (4) , 569-572
- https://doi.org/10.1111/j.1476-5381.1982.tb09175.x
Abstract
1 Intracerebroventricular administration of diazepam or midazolam decreased the antinociceptive effect of morphine in rats as measured by the ‘tail flick’ method. 2 Midazolam, injected into the periaqueductal grey matter (PAG) antagonized the analgesic effect of morphine. The action of midazolam was partially reversed by bicuculline. 3 These findings support the view that the effect of benzodiazepines on morphine antinociception may be mediated through γ-aminobutyric acid receptors.Keywords
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