Synthesis of L‐glutamic acid stereospecifically labeled at C‐4 with deuterium
- 1 January 1985
- journal article
- research article
- Published by Wiley in Journal of Labelled Compounds and Radiopharmaceuticals
- Vol. 22 (1) , 61-70
- https://doi.org/10.1002/jlcr.2580220109
Abstract
4‐[2H2]‐L‐glutamic acid was prepared in excellent yield by enzymatic reductive amination of 4‐[2H2]‐2‐ketoglutaric acid. The synthesis of stereospecifically deuterated (4 R) and (4 S)‐[4‐2H2]‐L‐glutamic acids from (2 RS, 4 S) and (2 RS, 4 R)‐4‐hydroxyglutamic acids, involving a reduction step by sodium cyanoborodeuteride, was shown to proceed with 75% inversion of configuration.Keywords
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