Prostaglandin analogs possessing antinidatory effects. 2. Modification of the .alpha. chain
- 1 May 1980
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 23 (5) , 525-535
- https://doi.org/10.1021/jm00179a011
Abstract
Additional double bonds were introduced into the .alpha. chain in 16-phenoxy-, 16-(3-chlorophenoxy)-, 16-[3-(trifluoromethyl)phenoxy]- and 16-(4-chlorophenoxy)-17,18,19,20-tetranorprostaglandins which have antinidatory effects. Of these analogs, the .DELTA.3-cis-.DELTA.5 analog 16-phenoxy-17,18,19,20-tetranor-3,4-trans,cis-didehydroprostaglandin F2.alpha. methyl ester is 1200 times more potent than prostaglandin F2.alpha. in antinidatory effect in the rat and more potent than any other known prostaglandin analogs.This publication has 1 reference indexed in Scilit:
- Prostaglandin analogs possessing antinidatory effects. 1. Modification of the .omega. chainJournal of Medicinal Chemistry, 1980