Specific Inhibition of Nuclear RNA Polymerase II by α-Amanitin
- 23 October 1970
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 170 (3956) , 447-449
- https://doi.org/10.1126/science.170.3956.447
Abstract
α-Amanitin, a toxic substance from the mushroom Amanita phalloides , is a potent inhibitor of DNA-dependent RNA polymerase II (the nucleoplasmic form) from sea urchin, rat liver, and calf thymus. This compound exerts no effect on the activity of polymerase I (nucleolar form) or polymerase III (also nucleoplasmic). The inhibition is due to a specific interaction with polymerase II or with a complex of DNA and polymerase II.Keywords
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