IMPROVED METHOD FOR ANALYZING SURVIVAL DATA FROM COMBINATION CHEMOTHERAPY EXPERIMENTS
- 1 January 1979
- journal article
- research article
- Vol. 39 (9) , 3446-3453
Abstract
A new method for analyzing survival data from combination chemotherapy experiments is presented. The analysis consists of relating survival to the dosage level of each drug in the combination and using response surface techniques to determine the importance of drug interactions and to estimate optimal doses. A combination experiment using cyclophosphamide, mechlorethamine, and mitomycin C in early mouse L1210 leukemia, advanced L1210 leukemia, and advanced P388 leukemia is used to illustrate the analyses. A therapeutic mouse synergism was shown. As a result of the various drug interactions, the predicted optimal dose of mitomycin C is zero. This result was duplicated in each tumor system studied.This publication has 7 references indexed in Scilit:
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