Aging Changes in Nucleic Acid and Protein-Forming Systems of the Virgin Mouse Uterus.

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Abstract
Changes in the total DNA, protein N, and the RNA/DNA ratio and water content were studied in the uteri of mice of strain 129 from 1 to 14 mos. of age. RNA/DNA (an estimate of relative RNA per cell) at the stimulated stages of the estrous cycle is max. at the time of max. uterine growth, between 2.5 and 5 mos. of age. The RNA/DNA of the uterus at the stimulated stages is higher than at diestrus at all ages. However, the differences between the diestrous values and that reached by the ratio at the stimulated stages slowly decreases with age. The cellular RNA content is significantly correlated with the water content of the uterus under the conditions studied and is also positively correlated with the amt. of protein N synthesized.