The Problem of Group Specificity in Allergy to Local Anesthetics
- 1 December 1950
- journal article
- research article
- Published by SAGE Publications in Journal of Dental Research
- Vol. 29 (6) , 713-717
- https://doi.org/10.1177/00220345500290060201
Abstract
Precipitation inhibition tests on a procaine-azoprotein antiserum of rabbits with different local anesthetic drugs gave evidence of a strong group specificity. Inhibition was restricted to those esterified derivatives of PABA in which the aromatic amino group has no side chain. To dentists allergic to one anesthetic of the procaine series, the use of local anesthetics with a different chemical structure and not derivatives of para-aminobenzoic acid is recommended.Keywords
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