Adaptation to High Altitude: Changes in Breath-Holding Time

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Abstract
Changes in maximal breath-holding time after breathing air or O2 as well as the alveolar gas concns. were recorded in 4 subjects during a 7-day exposure to an altitude of 14,000 ft. (4300 m). After the initial exposure to this altitude the breath-holding time on air as well as on O2 was gradually reduced over the next 5-7 days. Simultaneously the CO2 differences between the normal resting CO2 and that obtained at the breaking point were also reduced. These changes are interpreted as indicating an increased sensitivity of the respiratory system to CO2. The index of breath-holding time is suggested as a simple tool in evaluating respiratory adaptation to altitude.

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