Abstract
To study the effects of a reduced alkali reserve upon the breath-holding response, 6 subjects were given 15 g. NH4Cl/day for 3 days which resulted in an avg. reduction of the alkali reserve of 20%. The alveolar CO2 differences between rest and after a maximal breath-holding effort were analyzed every day and remained essentially unaltered. These results are discussed in light of high altitude acclimatization studies which show a marked reduction in the alveolar CO2 differences between rest and the breaking point and where the expected reduction of the alkali reserve is similar to that obtained in this study.

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