INFLUENCE OF VARIOUS METHODS OF SENSITIZATION ON DELAYED-HYPERSENSITIVITY TO BORDETELLA-PERTUSSIS IN SPRAGUE DAWLEY RAT

  • 1 January 1977
    • journal article
    • research article
    • Vol. 228  (1) , 162-170
Abstract
In the rat, the injection of B. pertussis produces, after prior sensitization, a delayed hypersensitivity inflammatory reaction within the pleural cavity. The influence of various methods of sensitization on this hypersensitivity was studied in the Sprague Dawley rat. The reaction was very variable according to the experimental conditions used. Optimal sensitization was obtained following the injection of antigen mixed with complete Freund''s adjuvant into the dorsal surface of the paws.