Bioavailability of Zinc from a Diet Based on Isolated Soy Protein: Application in Young Men of the Stable Isotope Tracer, 70Zn

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Abstract
With the aid of the stable isotope, 70Zn, as a tracer and neutron activation analysis, a combination of extrinsic labeling of meals and fecal monitoring of isotope excretion was used as a safe and noninvasive approach for assessing the effects of the vegetable (soy) and animal (milk, beef) proteins on the absorption of zinc in healthy, adult human volunteers. A known amount of 70Zn was added as ZnCl2, to six consecutive meals over a 2-day period during which either one of three isonitrogenous liquid formulas (skim milk; soy isolate; or a 50:50 mixture) or one of two bologna sausages (soy isolate or beef) were given. The mean absorption of 70Zn from milk, soy and soy/milk was 41 ± 4, 34 ± 4, and 41 ± 7% (mean ± sem), respectively, the presence of soy protein having no effect on absorption of the extrinsic label. For beef bologna and soy bologna, fractional absorption of the 70Zn tracer was 41 ± 4 and 30 ± 3%, respectively. Beef might favor absorption of extrinsic zinc. The kinetics of isotope excretion, pooling procedures for stool samples and the utility of fecal markers were also evaluated.