Effect of the cyclo-oxygenase inhibitor indobufen on platelet accumulation in prosthetic vascular grafts

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Abstract
An in vivo method of measuring thrombus deposition and pseudo‐intimal thickening in prosthetic arterial grafts in an animal model is described. The effect of indobufen, a new cyclo‐oxygenase inhibitor, was evaluated and compared to aspirin plus dipyridamole and placebo in 24 greyhounds. Luminal platelet accumulation expressed as thrombogenicity index was 0.33 ± 0.07 in the placebo group. This was significantly reduced to 0.14 ± 0.01 by indobufen (PPP< 0.02) compared to 75 ± 10 per cent found in the placebo group. This prosthetic graft model has considerable advantages in the evaluation of potential platelet inhibitory drugs for use in vascular surgery.