Enhanced mitotic recombination in a ligase-defective mutant of the yeast Saccharomyces cerevisiae.
- 1 September 1979
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 76 (9) , 4589-4592
- https://doi.org/10.1073/pnas.76.9.4589
Abstract
The temperature-sensitive S. cerevisiae cell cycle mutant cdc9 is defective in DNA ligase, and the DNA synthesized at the restrictive temperature contains many single-strand breaks. Holding a diploid homozygous for cdc9 at the restrictive temperature gives rise to increased intragenic and ingergenic recombination. In the latter case, recombinants signaled by the ade2 locus rise to about 4% of the survivors after 6 h of incubation at the restrictive temperature. The single-strand breaks left in DNA synthesized at the restrictive temperature may lead to recombination.This publication has 21 references indexed in Scilit:
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