UTERINE MOTILITY IN HYPOPHYSECTOMIZED AND IN PREGNANT RABBITS

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Abstract
In 5 rabbits hypophysectomized (confirmed by serial section of the sellae) by an intraorbital route on the 5th to 6th day of pregnancy or pseudopregnancy, the corpora lutea lost within 48 hrs. their power to inhibit typical uterine contractions induced by oestrin (Theelin). In 21 unanesthetized pregnant rabbits tested, the uterus was refractory to the motility-inducing action of Theelin until the 26th day of pregnancy, but on the 27th day the injection of Theelin led to abortion and death. The exps. show that the corpus luteum functions at a high level, as regards maintaining uterine quiescence, until about the middle of the 4th wk. of gestation, and is no longer functioning in this regard by the end of the 4th wk.

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