Cleavage of specific sites of RNA by designed ribozymes
- 7 November 1988
- journal article
- Published by Wiley in FEBS Letters
- Vol. 239 (2) , 285-288
- https://doi.org/10.1016/0014-5793(88)80935-9
Abstract
Two ribozymes were designed for site-specific cleavage of RNA. A UA site in an undecaribonucleotide was cleaved by a ribozyme consisting of two partially paired oligoribonucleotides with chain lengths of 19 and 15. The other ribozyme, which consists of a 19-mer and a 13-mer, recognized a UC sequence at positions 42 and 43 of 5 S rRNAKeywords
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