Influence of Pre- and Post-X-Irradiation Zymosan Administration on Reticuloendothelial Function

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Abstract
Phagocytic activity, evaluated by the intravascular removal rate of colloidal carbon, was determined in mice injected with the reticulo-endothelial (RE) stimulating agents, trypsinized zymosan and glucan, either prior to or immediately after exposure to 1000 r. Half-times (t/2), global phagocytic activity (K), corrected phagocytic activity ([alpha]), and weight changes of liver and spleen were determined at frequent postirradiation intervals. The profound post irradiation hyperphagocytic state induced by prior injection of zymosan was unaltered. Phagocytic function was significantly impaired in normal mice 96 hours after exposure. In contrast, the injection of zymosan after exposure maintained normal RE function but did not induce a hyperfunctional state. Post irradiation survival at various doses was unaltered by zymosan or glucan induced RE stimulation.