Infections in compromised hosts: Modified susceptibility of tumor-bearing mice to experimental infection with Proteus morganii strain 1510.

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Abstract
When 3.2 .times. 106 viable cells of P. morganii strain 1510 were injected i.v. into mice, having received transplantation of Sarcoma-180 (S-180) 4 days (ST4 mice) or 8 days (ST8 mice) before bacterial infection, all mice died; no deaths occurred in non-tumor-bearing mice. After inoculation with 3 .times. 106 viable bacteria, reduction of the bacterial counts in the liver, spleen and kidney of the S-180 bearing mice was slower than that in normal mice. The bacteria in the organs of ST4 mice started to multiply 4-8 h postinoculation and reached 105-106 viable cells within 24 h. In these tumor-bearing mice, absolute leukocytosis was noted. Phagocytosis and intracellular bactericidal activity of phagocytes against the inoculated bacteria in S-180-bearing mice were approximately the same as those in normal mice. In the tumor-bearing mice, serum factors for opsonization of the inoculated bacteria were markedly impaired.