Effect of an Aldosterone Antagonist on Electrolytes and Juxtaglomerular Granularity in Adrenal Regeneration Hypertension

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Abstract
Aldactone (SC-9420, spironolactone), an aldosterone antagonist, prevents the increased blood pressure, increased renal weight and shift of potassium out of skeletal muscle cells which occur with adrenal regeneration after enucleation. It also prevents juxtaglomerular (JG) degranulation due to salt feeding in unilaterally nephrectomized, saline-fed controls, but not in unilaterally nephrectomized, saline-fed, adrenal-enucleated rats. The reason for this difference between enucleated and control rats is unknown. Aldactone prevents atrophy of the zona glomerulosa due to saline feeding in control animals. There is a significant positive linear relationship between log zona glomerulosa width and JG granularity, indicating intervention by Aldactone in the renin-angiotensin- aldosterone mechanism. In control rats Aldactone increases serum potassium, muscle intracellular potassium, and muscle intracellular water without much effect on sodium. (Endocrinology75: 326,1964)

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