HYPERACUTE REJECTION OF A KIDNEY ALLOGRAFT MAY BE CAUSED BY CYTOTOXIC LYMPHOCYTES

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Abstract
A case of hyperacute rejection of a kidney allograft is described in relation to the clinical, patho-anatomical and immunological findings. An 18 yr old male was allotransplanted for the 3rd time with a necrokidney from an unrelated HLA-A and B, full house identical and bloodgroup ABO identical donor. Serological crossmatches performed with recipient sera harvested before and after transplantation were negative. However, the kidney suffered hyperacute rejection according to clinical and patho-anatomical criteria. The cellular complement independent cytolytic capacity of recipient lymphocytes drawn before and after transplantation against donor lymphocytes was tested by the direct Cell Mediated Lympholysis (CML) test. This test was positive 24 h after transplantation; it was negative before this. Lymphocytolysis was enhanced by inactivated recipient serum harvested before and after transplantation. Hyperacute rejection of a kidney allograft may be ascribed to presensitized, not necessarily circulating, effector lymphocytes alone or in concert with antibody(ies) not disclosed by conventional crossmatching.