Chromosome mosaicism of the placenta—a cause of developmental failure of the fetus?
- 1 September 1989
- journal article
- research article
- Published by Wiley in Prenatal Diagnosis
- Vol. 9 (9) , 639-647
- https://doi.org/10.1002/pd.1970090907
Abstract
Fourteen (2.5 per cent) of 568 chromosome preparations after CVS showed discrepancies between the placental and fetal karyotype, mainly due to placental mosaicism. The presence of a second cell line within the placenta was confirmed in all but one case, in which cytogenetic reinvestigations were carried out. Our clinical data indicate that severe developmental retardation in the newborn is not to be expected if only the placenta carries the chromosomally abnormal cell line.Keywords
This publication has 18 references indexed in Scilit:
- Trisomy 7 in chorionic villi: Follow‐up studies of pregnancy, normal child, and placental clonal anomaliesPrenatal Diagnosis, 1988
- Trisomy 14 mosaicism leading to cytogenetic discrepancies in chorionic villi sampled at different timesPrenatal Diagnosis, 1988
- Prenatal cytogenetic diagnosis after transabdominal chorionic villus sampling in the first trimesterPrenatal Diagnosis, 1988
- Chorionic villi sampling: cytogenetic and clinical findings in 500 pregnancies.BMJ, 1987
- Transzervikale Chorionbiopsie - Bisherige Erfahrungen und Ergebnisse aus mehr als 200 Fällen*Geburtshilfe und Frauenheilkunde, 1987
- TRANSABDOMINAL CHORION VILLUS BIOPSY: 100 CONSECUTIVE CASESThe Lancet, 1987
- Chorionic villus sampling: An analysis of the obstetric experience of 1000 casesPrenatal Diagnosis, 1987
- Abnormal karyotype in the chorion, not confirmed in a subsequently aborted fetusPrenatal Diagnosis, 1986
- Chorionic villus culture for first trimester diagnosis of chromosome defects: Evaluation by two london centresPrenatal Diagnosis, 1986
- Chromosomal Mosaicism Confined to the Placenta in Human ConceptionsScience, 1983