Influence of Autonomic Blockade on Aconitine Induced Pulmonary Edema.

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Abstract
Summary 1. Bilateral injection of aconitine into the preoptic areas of rats results in a marked rise in systemic arterial pressure and a rise in pulmonary venous pressure followed or accompanied by development of severe pulmonary edema. 2. Pulmonary edema from preoptic injection of aconitine or from infused epinephrine occurs at femoral arterial pressures near 200 mm Hg. 3. Since the rise in blood pressure and the accompanying edema is largely prevented by the sympatholytic agents, phentolamine and dibenzyline, the preoptic injection of aconitine appears to act primarily by causing a central sympathetic discharge. 4. It is postulated that the pulmonary edema produced by preoptic injection of aconitine results, as with epinephrine, from inability of the left ventricle to maintain its output against an increased peripheral resistance which leads to back pressure effects on the pulmonary venous and capillary vessels. 5. Atropine in doses of 20 mg/kg does not significantly modify the edema production.

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