On‐line adaptive control of a fed‐batch fermentation of Saccharomyces cerevisiae

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Abstract
The feasibility of applying an adaptive control technique to a fermentation process is investigated. The nonlinear, time‐variant parameters of a fermentation process were estimated on‐line as a series of linearized describing matrices. The matrices were used to update a suboptimal feedback law which controlled the process in real time over the linear region. Experiments were performed on a small‐scale fully instrumented fermenter with the online, real‐time adaptive control package. Results are presented for both single‐ and multivariable control, and indicate successful control of yeast cell growth.